Phenylalanine hydroxylase activity and expression in chicks subjected to phenylalanine imbalance or phenylalanine toxicity
نویسندگان
چکیده
منابع مشابه
Phenylalanine requirement, imbalance, and dietary excess in one-week-old chicks: growth and phenylalanine hydroxylase activity.
Two experiments were performed to study Phe imbalance and toxicity in 1-wk-old Babcock B380 chicks resulting from the addition of either a mixture of indispensable amino acids lacking Phe (IAA - Phe) or excess Phe to a diet that was nutritionally adequate in Phe. Chicks received a preexperimental semipurified diet for 1 wk and experimental diets from 7 to 14 d of age. In the first experiment, t...
متن کاملMouse phenylalanine hydroxylase. Homology and divergence from human phenylalanine hydroxylase.
The laboratory mouse represents an important model for the study of phenylalanine metabolism and the pathochemistry of phenylketonuria, yet mouse phenylalanine hydroxylase (PAH) has not been extensively studied. We report the cloning and sequencing of a mouse PAH cDNA, the expression of enzymic activity from the mouse PAH cDNA clone and the identification of mouse PAH and human PAH by two-dimen...
متن کاملMechanism of phenylalanine regulation of phenylalanine hydroxylase.
The mechanism of phenylalanine regulation of rat liver phenylalanine hydroxylase was studied. We show that phenylalanine "activates" phenylalanine hydroxylase, converting it from an inactive to active form, by binding at a true allosteric regulatory site. One phenylalanine molecule binds per enzyme subunit; it remains at this site during catalytic turnover and, while there, cannot be hydroxylat...
متن کاملLiver phenylalanine hydroxylase activity in relation to blood concentrations of tyrosine and phenylalanine in the rat.
The plasma concentration of phenylalanine and tyrosine decreases in normal rats during the first few postnatal days; subsequently, the concentration of phenylalanine remains more or less constant, whereas that of tyrosine exhibits a high peak on day 13. The basal concentrations of the two amino acids were not altered by injections of thyroxine or cortisol, except in 13-day-old rats, when an inj...
متن کاملPhenylalanine hydroxylase: metabolic aspects.
Phenylalanine hydroxylase [L-phenylalanine,tetrahydropteridine :oxygen oxidoreductase (4-hydroxylating); EC 1.14.16.11 catalyses the first reaction in the irreversible catabolism of the essential amino acid phenylalanine. Studies of the isolated enzyme and of phenylalanine metabolism in viuo and in oitro support the view that the hydroxylase plays the major role in regulating phenylalanine disp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Poultry Science
سال: 2009
ISSN: 0032-5791
DOI: 10.3382/ps.2008-00370